Caren Chang Lab
Ethylene hormone signaling
Selected Publications
Li et al. (2021) Something old, something new: conservation of the ethylene precursor ACC as a signaling molecule. Curr. Opin. Plant Biol. 65: 102116. doi: 10.1016/j.pbi.2021.102116
Li et al. (2020) Ethylene-independent functions of the ethylene precursor ACC in Marchantia polymorpha. Nat. Plants 6: 1335-1344.
Mou et al. (2020) Ethylene-independent signaling by the ethylene precursor ACC in Arabidopsis ovular pollen tube attraction. Nat. Comm. 11: 4082. https://rdcu.be/b6gjv
Tomoaki Nishiyama et al. (2018) The Chara Genome: Secondary Complexity and Implications for Plant Terrestrialization. Cell 174: 448-464.
https://doi.org/10.1016/j.cell.2018.06.033
Delwiche C.F., Goodman C. and Chang C. (2017) Land plant model systems branch out. Cell 171: 265-266. https://doi.org/10.1016/j.cell.2017.09.036
Chang C., Bowman J.L. and Meyerowitz E.M. (2016) Field guide to plant model systems. Cell 167: 325–339. dx.doi.org/10.1016/j.cell.2016.08.031
Van de Poel B., Cooper E.D., Van der Straeten D., Chang C. and Delwiche C.F. (2016) Transcriptome profiling of the green alga Spirogyra pratensis (Charophyta) suggests an ancestral role for ethylene in cell wall metabolism, photosynthesis and abiotic stress responses. Plant Physiol. 172: 533-545 doi:10.1104/pp.16.00299.
Chang C. (2016) How do plants respond to ethylene and why is this important? BMC Biology 14: 7
Ju C. and Chang C. (2015) Mechanistic insights in ethylene perception and signal transduction. Plant Physiol., 169: 85-95.
Ju C., Van de Poel B., Cooper ED., Thierer J., Gibbons TR., Delwiche CF., and Chang C. (2015) Conservation of Ethylene as a Plant Hormone over 450 Million Years of Evolution. Nature Plants 1, Article 14004. doi: 10.1038/nplants.2014.4.
Chang J., Clay J.M., and Chang C. (2014) Association of cytochrome b5 with ETR1 ethylene receptor signaling through RTE1 in Arabidopsis. Plant J. 77: 558-567.
Chang C. and Bowman J.L. (2013). From cell to organism across space and time. Curr Opin Plant Biol. 16: 542-544.
Ju C.,Yoon G., Shemansky J., Lin D., Ying Z.I., Chang J., Garrett, W. Kessenbrock M., Groth G., Tucker M.L., Cooper B., Kieber J.J., and Chang C. (2012) CTR1 phosphorylates EIN2 to control ethylene signaling from the ER membrane to the nucleus. Proc. Natl. Acad. Sci. USA 109: 19486-19491.
Ju C. and Chang C. (2012) Advances in ethylene signalling: protein complexes at the endoplasmic reticulum membrane. AOB Plants Article number pls031.
Asensi-Fabado, M.A., Cela J., Muller M., Arrom L., Chang C., and Munne-Bosch S., (2012) Enhanced oxidative stress in the ethylene-insensitive (ein3-1) mutant of Arabidopsis thaliana exposed to salt stress. J. Plant Physiol.196: 360-368.
Chen R., Binder B., Garrett W.M., Tucker M.L., Chang C. and Cooper B. (2011) Proteomic responses in Arabidopsis thaliana seedlings treated with ethylene. Mol. BioSyst. 7: 2637-2650.
Cela J., Chang C., and Munne-Bosch S. (2011) Accumulation of gamma-rather than alpha-tocopherol alters ethylene signaling gene expression in the vte4 mutant of Arabidopsis thaliana. Plant Cell Physiol. 52: 1389-1400.
Dong CH, Jang M, Scharein B, Malach A, Rivarola M, Liesch J, Groth G, Hwang I., and Chang C. (2010) Molecular association of the Arabidopsis ETR1 ethylene receptor and a regulator of ethylene signaling, RTE1. J Biol. Chem. 52: 40706-40713
Rivarola M., McClellan C.A., Resnick J.S. and Chang C. (2009) ETR1-specific mutations distinguish ETR1 from other Arabidopsis ethylene receptors as revealed by genetic interaction with RTE1. Plant Physiol. 150: 547-551
Resnick J.S., Rivarola M. and Chang C. (2008) Involvement of RTE1 in conformational changes promoting ETR1 ethylene receptor signaling in Arabidopsis. Plant J. 56: 423-431
Gao Z., Wen C.-K., Binder B.M., Chen Y.-F, Chang J., Chiang Y.-H., Kerris R.J. III, Chang C. and Schaller G.E. (2008) Heteromeric interactions among ethylene receptors mediate signaling in Arabidopsis. J. Biol. Chem. 283: 23801-23810
Kendrick M.D. and Chang C. (2008) Ethylene signaling: new levels of complexity and regulation. Curr. Opin. Plant Biol. 11: 479-485
McClellan C.M. and Chang C. (2008) The role of protein turnover in ethylene biosynthesis and response. Plant Science 174: 24-31.
Dong C.-H., Rivarola M., Resnick J.S., Maggin B.D. and Chang C. (2008) Subcellular co-localization of Arabidopsis RTE1 and ETR1 supports a regulatory role for RTE1 in ETR1 ethylene signaling. Plant J. 53: 275-86
Gao Z., Wen C.K., Binder B.M., Chen Y.F., Chang J., Chiang Y.H. Ill R.J.K., Chang C., and Schaller G.E. (2008) Heteromeric interactions among ethylene receptors mediate signaling in Arabidopsis. J. Biol. Chem. 283: 23801-23810.
Resnick J.S. and Chang C. (2007) Ethylene. In: Encyclopedia of Life Sciences (John Wiley & Sons, Ltd, Chichester) http://www.els.net/ [doi:10.1002/9780470015902.a0020099].
Chang C. (2007) Ethylene biosynthesis, perception, and response. J. Plant Growth Regul. 26: 89-91.
Wang W., Esch J.J., Shiu S., Agula H., Binder B.M., Chang C., Patterson, S.E. and Bleecker A.B. (2006) Identification of important regions for ethylene binding and signaling in the transmembrane domain of the ETR1 ethylene receptor of Arabidopsis . Plant Cell 18: 3429- 3442.
Resnick J.S., Wen C.-K., Shockey J.A. and Chang C. (2006) REVERSION-TO-ETHYLENE SENSITIVITY1, a conserved gene that regulates ethylene receptor function in Arabidopsis. Proc. Natl. Acad. Sci. USA 103: 7917-7922.
Chang C., Bleecker A.B. (2004) Ethylene biology. More than a gas. Plant Physiol. 136: 2895-2899.
Chang C. (2003) Ethylene signalling: the MAPK module has finally landed. Trends Plant Sci. 8: 365-368.
Mount S.M. and C. Chang (2002) Evidence for a plastid origin of plant ethylene receptor genes. Plant Physiol. 130: 10-14.
Wen C.K. and C. Chang (2002) Arabidopsis RGL1 encodes a negative regulator of gibberellin responses. Plant Cell 14: 87-100.
Chang C., R. Stadler (2001) Ethylene hormone receptor action in Arabidopsis. BioEssays 23: 619-627.
Larsen P.B., C. Chang (2001) The Arabidopsis eer1 mutant has enhanced ethylene responses in the hypocotyl and stem. Plant Physiol. 125: 1061-1073.
Pan Z. and C. Chang (1999) Functional complementation of the S. pombe wis1 mutant by Arabidopsis MEK1 and noncatalytic enhancement by CTR1. FEBS Lett. 459: 405-410.
Chang C. and J.A. Shockey (1999) The ethylene-response pathway: Signal perception to gene regulation. Curr. Opin. Plant Biol. 2: 352-358.
Chang C. and R.C. Stewart (1998) The two-component system: Regulation of diverse signaling pathways in prokaryotes and eukaryotes. Plant Physiol. 117: 723-731.
Sakai H., J. Hua, G. Chen, C. Chang, L.J. Medrano, A.B. Bleecker and E.M. Meyerowitz (1998) ETR2 is an ETR1-like gene involved in ethylene signaling in Arabidopsis. Proc. Natl. Acad. Sci USA. 95: 5812-5817.
Clark K.L., P.B. Larsen, X. Wang and C. Chang (1998) Association of the Arabidopsis CTR1 Raf-like kinase with the ETR1 and ERS ethylene receptors. Proc. Natl. Acad. Sci USA. 95: 5401-5406.
Chang C., Clark K.L., Jirage D.,Ding W.M., Wang X.X., Cross R. (1997) Ethylene signal transduction: two-component receptors and Raf-like kinase CTR1. Plant Physiology 114: 40001-40001
Wilkinson J.Q., M.B. Lanahan, D.G. Clark, A.B. Bleecker, C. Chang, E.M. Meyerowitz and H.J. Klee (1997) A dominant mutant receptor from Arabidopsis confers ethylene insensitivity in heterologous plants. Nature Biotech. 15: 444-448.
Chang C. (1996) The ethylene signal transduction pathway in Arabidopsis: An emerging paradigm? Trends Biochem. Sci. 21: 129-133.
Chang C., Meyerowitz E.M. (1995) The ethylene hormone response in Arabidopsis - A euaryotic 2-component signaling system. Proc. Natl. Acad. Sci. USA. 92: 4129-4133.
Hua J., C. Chang, Q. Sun and E.M. Meyerowitz (1995) Ethylene insensitivity conferred by Arabidopsis ERS gene. Science 269:1712-1714.
Chang C., Meyerowitz E.M. (1994) Eukaryotes have 2-component signal transducers. Research in Microbiology 145: 481-486.
Chang C., S.F. Kwok, A.B. Bleecker and E.M. Meyerowitz (1993) Arabidopsis ethylene-response gene ETR1: Similarity of product to two-component regulators. Science 262: 539-544.
Chang C., Bowman J.L., DeJohn A.W., Lander E.S., Meyerowitz E.M. (1988) Restriction fragment length polymorphism linkage map for Arabidopsis thaliana. Proc. Natl. Acad. Sci. USA. 85: 6856-6860.
Chang C. and Meyerowitz E.M. (1986) Molecular cloning and DNA sequence of the Arabidopsis thaliana alcohol dehydrogenase gene. Proc. Natl. Acad. Sci. USA 83: 1408-1412.
The image shows the charophyte alga Chara braunii consisting of two oval oogonia (female gametangia) with smaller, round-shaped antheridia (male gametangia). Chara represents the common ancestor that gave rise to all land plants, which are depicted as a moss, fern, gymnosperm, and angiosperm plant within the gametangia. Image credit: Photo by Melanie Barth, Rensing Lab, University of Marburg; artwork by Debbie Maizels, Zoobotanica.
The ethylene signaling pathway known in land plants was recently found to be conserved in Spirogyra pratensis (a filamentous Charophycean green alga). Ethylene treatment of Spirogyra induces elongation of the cells within the filament, as shown. A transcriptomic analysis of the ethylene response in Spirogyra by Van de Poel et al. (pp. 533-545) suggests changes in cell wall metabolism, photosynthesis and abiotic stress responses. The cover image shows confocal microscopy of two Spyrogyra filaments, one with normal-sized cells (left) and the other with elongated cells (right). To create the image, a confocal section of DAPI-stained (blue) filaments, showing cell walls, was overlaid with the autofluorescence (red) of chlorophyll in the spiral chloroplasts. The image was produced by Dr. Bram Van de Poel.